What if there was a compound that could turn back time, restore energy, improve athletic performance, bring back clarity of thought, reverse depression and help cure cravings for alcohol and drugs even in the most addicted individuals?

There is such a substance. It is called NAD+, and it occurs naturally in every cell in your body.

Compelling research has shown that supplementing with NAD+ may help you withdraw from addictive substances safely, overcome anxiety and depression, handle acute and chronic stress more effectively, and cope better with PTSD.

In fact, clinics across the US are starting to use IV infusions of NAD+ to help people withdraw from drug and alcohol addiction with minimal symptoms in as little as 7-14 days of treatment. These individuals report feeling calm and content and say they lost their “cravings” after a full course of treatment.

And NAD+ may actually prolong life, protect DNA, slow down aging and help restore function in neurodegenerative illness due to its effects on the genes that govern aging.

Unfortunately, drugs, alcohol, stress, medications, chronic illness and age all contribute to a decrease in our NAD+ stores. As NAD+ goes down, so does our energy. Cells age and deteriorate. Your health falls apart at the very root.

This IV aims to undo that process by replenishing NAD+. Using IV infusion therapy we administer this anti-aging compound directly into your blood circulation so your cells have access to as much as they need.

Between 3-14 consecutive days of NAD+ therapy combined with amino acid infusions, minerals, and B-Vitamins are typically recommended for full effect. Treatment is tailored to your individual needs after a detailed consultation.

 

Science

The nicotinamide adenosine dinucleotide (NAD) molecule alternates between two forms. Which one is present depends on how it is being utilized. NAD+ is the reduced (active) form of the molecule. NADH is the oxidized (inactive) form of the same molecule.

Energy production in your mitochondria—the little energy factories that pump out ATP—ABSOLUTELY depends on NADH (the inactive form) being recycled back to active NAD+. If this recycling stops and NADH accumulates the cell runs out of energy and it may die. This was clearly shown in a recent study on brain and kidney cells.1

It goes without saying, then, that depleted levels of NAD+ and accumulation of NADH, or a low ratio of NAD+/NADH, can create problems for your mitochondria and your cells. Indeed, it results in low levels of cellular energy and may be one of the primary contributing factors to “mitochondrial dysfunction”. a condition we now know is implicated in a wide variety of chronic illnesses including autoimmune disorders, diabetes, and others.

Restoring NAD+ levels reverses this process and allows cells to return to full energy status, offering a possible way to undo mitochondrial damage and the resulting chronic illness.

NAD+ as an Anti-Aging Molecule

Medical researchers have long known that a group of enzymes called sirutins play a crucial role in how the body ages—especially SIRT1 and SIRT3. We don’t yet understand precisely how they work, but what we do know is exciting. SIRT enzymes appear to switch off genes that promote aging such as those that cause inflammation, fat synthesis and storage, and blood sugar management issues.

Up until now the only way we knew to positively impact these SIRT enzymes was to go on a very low-calorie diet. As uncomfortable as it may be, caloric restriction is one of the few ways that has repeatedly been shown to lead to a longer life.

However, the tide appears to be turning. You see, recent research indicates that NAD+ plays a key role in the creation and activation of the sirutins.

Doctors out of the Department of Developmental Biology at the Washington University School of Medicine were the first to show this link in 2014.2 The authors note:

“NAD(+) levels decline during the aging process and may be an Achilles’ heel, causing defects in nuclear and mitochondrial functions and resulting in many age-associated pathologies. Restoring NAD(+) by supplementing NAD(+) intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases.”

These findings were corroborated in 2016 when the scientific journal Rejuvenation published an article where the authors discussed how low NAD+ levels are DIRECTLY associated with cellular aging, and they emphasized that this process can be prevented by increasing the levels of NAD+ within cells.

So is NAD+ a fountain of youth? It could be. More research needs to be done. But one thing seems clear: It certainly has an impact on your body at the cellular level, and it may just turn back the hands of time.

NAD+’s Role in Exercise and Endurance

It is well known that ATP levels get depleted in muscles while exercising. This simply stands to reason. However, until recently we didn’t know how NAD+ was implicated in this process.

A study done in 2010 using both trained and untrained healthy volunteers helped tease out the relationship. The researchers showed that intense exercise decreases NAD+. When the study participants took an antioxidant supplement containing pycgnogenol (which stimulates NAD+ production and protects it from turning into the inactive, oxidized form of the molecule), NAD+ levels increased and exercise performance and “time to fatigue” also improved.3

Using a direct IV infusion of NAD+ is certainly a more efficient way of raising NAD+ levels than taking an indirect, oral supplement that acts as a stimulator for NAD+. So we know that this IV can improve athletic performance, and it likely has a more pronounced effect than the study cited above.

NAD+’s Role in Reversing Chronic Illness and Neurodegenerative Disease

At the end of the day, health and energy production are intimately related. If your mitochondria aren’t functioning or they are producing too little energy, you are going to experience symptoms. When the problem becomes too severe it turns into illness.

The link between NAD+, energy production, and chronic illness really couldn’t be clearer. Low NAD+ results in low ATP levels. Low ATP levels quickly depletes your cell’s energy reserves. Left unchecked, and this can lead to cell death.

How all of this shows up in your body depends on which cells are being affected. If nerve cells are affected, the lack of energy may manifest itself as depression, anxiety, fatigue and lack of focus. In severe cases where the nerve cells are dramatically impacted or even die, neurodegenerative illness like Parkinson’s disease and Multiple Sclerosis may manifest themselves. In the worst cases—like mass cellular death—this may lead not only transient symptoms such as tremors, spasms, tingling, numbness and blurred vision, but to permanent, irreversible disability.

If your heart cells are affected, it can lead to cardiovascular disease. If your lung cells are affected pulmonary disorders may present themselves. Basically, when the cells in your organs and tissues don’t have enough energy, illness results.

IV NAD+ combined with IV amino acids can be beneficial in restoring energy production—especially in the nerve tissue—and may even prevent permanent damage.

One 2014 study showed that rat nerve cells pre-treated with high concentrations of NAD+ before being deprived of oxygen survived the challenge and recovered much faster than cells not bathed in the extra protective NAD+.4

A more recent review article published in 2015 builds on this. After scientists examined all of the available scientific evidence they recommended NAD+ supplementation and restoration as a new therapeutic opportunity for a wide variety of neurodegenerative diseases.5

Some of the conditions which may benefit from NAD+ infusion therapy include:

• Multiple Sclerosis
• Parkinson’s disease
• Alzheimer’s disease
• Chronic Fatigue
• Fibromyalgia
• Mitochondrial Dysfunction

References

1 Chance, Britton, et al. “Intracellular Oxidation-Reduction States in Vivo The microfluorometry of pyridine nucleotide gives a continuous measurement of the oxidation state.” Science 137.3529 (1962): 499-508.

2 Imai, Shin-ichiro, and Leonard Guarente. “NAD+ and sirtuins in aging and disease.” Trends in cell biology 24.8 (2014): 464-471.

3 Mach, John, et al. “The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+ (H).” Nutrients 2.3 (2010): 319-329.

4 Shetty, Pavan K., Francesca Galeffi, and Dennis A. Turner. “Nicotinamide pre-treatment ameliorates NAD (H) hyperoxidation and improves neuronal function after severe hypoxia.” Neurobiology of disease 62 (2014): 469-478.

5 Verdin, Eric. “NAD+ in aging, metabolism, and neurodegeneration.” Science 350.6265 (2015): 1208-1213.

6 Cederbaum, Arthur I. “Alcohol metabolism.” Clinics in liver disease 16.4 (2012): 667-685.